p53 Amino Acids 339–346 Represent the Minimal p53 Repression Domain
نویسندگان
چکیده
منابع مشابه
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.
Many DNA tumor viruses express a protein that inhibits transcriptional activation by the tumor-suppressing transcription factor p53. We report that adenovirus E1B 55K represses p53-mediated activation by a mechanism not described previously. E1B 55K binds p53 without displacing it from its DNA-binding site. A fusion of E1B 55K to the GAL4 DNA-binding domain represses transcription from a variet...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m008231200